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Could a pill make your body act as though it’s exercising?

WASHINGTON — Scientists have created a metabolism-boosting molecule that mimics the effect of exercise on a cellular level.

The new molecule, called “compound 14,” caused obese mice being fed a high-fat diet to lose about 5 percent of their body weight in a week, according to research published in the journal Chemistry and Biology.

Scientists from the University of Southampton say the molecule they’ve created has no impact on mice of normal weight eating a normal diet.

Compound 14 works by triggering a domino effect that alters cellular metabolism. It blocks the functionality of the enzyme ATIC, causing levels of the molecule ZMP to build up — a signal to cells that they have run out of energy.

The cells respond by attempting to increase energy by eating more glucose and boosting metabolism.

Looking ahead, researchers say this new molecule needs to be developed further in order to examine long-term effects. But they add that if compound 14 is found to be safe, it could lead to a drug to help manage obesity and diabetes.

States seek to lower drug prices by targeting the companies that manage them for health plans

TOPEKA, Kan. (AP) — As consumers worry about medication costs, states are trying to lower drug prices by reining in big companies that oversee prescription coverage for health insurers. Some of those companies, called pharmacy benefit managers, also own pharmacies, and one of them, CVS, has spent millions of dollars fighting the regulations. Affordability is a key issue ahead of this year’s midterm elections. Legislators in at least a dozen states passed laws this year to limit compensation to the companies, set minimum payments from the companies to pharmacists and require the companies to disclose more information to their clients, states and the public. A Tennessee law will bar pharmacy benefit managers from operating retail pharmacies as of July 1, 2028, though CVS Health Corp. has filed a federal lawsuit to avoid having to close its 136 pharmacies there.
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